Genetic Determinants Of Hiv Infection - 807 Words

Genetic determinants of HIV infection: HIV has two major types: HIV-1 and HIV-2. HIV-1 has four groups M, N, O and P. These groups are further classified into subtypes. Group M is a major infecting group worldwide contributing to 90% of HIV-1 infections. Group M is classified into nine subtypes (A, B, C, D, E, F, G, H, J and K). Subtype B is predominantly found in America and Western Europe. The susceptibility to HIV-1 infection, transmission of disease, and response to retroviral therapy depend on the genetic determinants of the host cell. These genetic determinants vary in populations and among patients. These genetic variants regulate chemokine co-receptors and ligands that involve in the entry of the virus, major histocompatibility complex, killer cells Ig like receptor and cytokines, and TRIM5ÃŽ ± motif and apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (Kaur and Mehra, 2009). In genome-wide association studies performed in European population, it was shown that Human leukocyte antigen (HLA) cla ss I variation (Eg. HLA-B*5701) is the major contributor to viral set point and CD4+ T cell decline (Fellay et al., 2010). Cohort study of genetic polymorphism in chemokine receptors in Indian population has shown that protective CCR5 Δ32 variant is rare and CCR5HHE carrying *59402A has the high likelihood of infections (Kaur and Mehra, 2009). HIV Sequence Database contains annotated HIV sequencesShow MoreRelatedThe Health Of The Population Health937 Words   |  4 Pagescombination (Knickman Kovner, 2015). These determinants of health, known as population health determinants generally include genetics, access to health care, individual behavior, social determinant, physical environment (Knickman Kovner, 2015). Determinant factors are fundamental to the prevention of disease, illness, and injury because it illustrates health dispositions on why some individual or population are in better health than another counterpart. HIV/AID is the population health issue I selectedRead MoreThe Health Of The Modern Health Care968 Words   |  4 Pagescombinations (Knickman Kovner, 2015). These determinants of health, known as population health determinants generally include genetics, access to health care, individual behavior, social determinant, physical environment (Knickman Kovner, 2015). Determinant factors are fundamental to the prevention of disease, illness, and injury because it illustrates health dispositions on why some individual or population are in better health than another counterpart. HIV/AID is the population health issue I selectedRead MoreHealth Determinants Affecting A Population s Health Essay1549 Words   |  7 Pagesassignment is on how health determinants affect a population’s health, I do understand what health is which is being at a states of wellness or free from illness or injury. Or as close to that state as possible because a patient can have a chronic condition and still be at a state of good health just not as good as a person who is free of disease, injury or illness. And I know a determinant is something that determines or effects the outcome of something. So a health determinant to me would be anythingRead MoreEpidemiology HIV Paper1382 Words   |  6 PagesCanyon University: NRS- 427V 12/14/2014 HIV COMMUNICABLE DISEASE AIDS (Acquired Immunodeficiency Syndrome) is defined by the Mayo Clinic as A chronic, potentially life-threatening condition which is caused by the human immunodeficiency virus (HIV). 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Description of the communicable disease (causes, symptoms, mode of transmission, complications, treatment) and the demographic of interest (mortality, morbidity, incidence, and prevalence). 2. Describe the determinants of health and explain how those factors contribute to the development of this disease. 3. DiscussRead MoreHiv Epidemiology1228 Words   |  5 PagesHIV Epidemiology HIV Epidemiology For the epidemiology paper I chose to write about HIV. HIV is growing concern in the community and too many people are uneducated about the seriousness of this disease. HIV is terminal illness; it will eventually consume your life at some point. There are treatment options out there but being compliant with the medication regimen is crucial to the maintenance and management of this disease. HIV also known as the Human Immunodeficiency Virus; with HIV the virusRead MoreHiv / Aids : A Global Health System1606 Words   |  7 PagesHIV/AIDS: A global health system Rita K. Asiedu Rutgers University Abstract Human immunodeficiency virus (HIV)/AIDS is a pandemic problem affecting global health. At the end of 2015, 36.7 million people were living with HIV/AIDS globally. The rate of incidence is more prevalent in Sub-Saharan Africa with almost 1 in every 24 adults living with HIV/AIDS. In the united states, HIV/AIDS is a diversified health problem affecting all sexes, ages and races and involving the transmission of multipleRead MoreEpidemiology Is A Medical Science Discipline That Arranges1687 Words   |  7 PagesEpidemiology is a medical science discipline that arranges the structure for studying the distribution and determinants of health, communicable disease, and circumstances related to health status. The epidemiology research help to understand in what means a person catch diseases, the changes, and how the disease affect the population. The nurses that work with these communities to help identify the onset of communicable diseases determine new victims, the patterns it spread, th e causes or preventive

Driving The Cost Of Higher Education - 1063 Words

Driving the Cost of Higher Education It seems as though the correct step for young people to follow after high school is college. We are constantly told that if we wish to be successful, then we must get a degree. However, with the rising costs, it’s seeming like fewer people are willing or able to take the next step into higher education. Cries about the sheer insanity of the rising costs blur into a cacophony of anger and frustration. The discussion of whether it’s even worth the cost have also begun becoming popular, though this is its own discussion and shall not be explored here. What is of interest here is the underlying motor of the cost increase. Since 1978, the first year that the Bureau of Labor and Statistics included college†¦show more content†¦Perhaps this is because their costs do not react as fast to market forces as does the private sector. Prices are normally set, and then remain relatively stable regardless of the day-to-day changes in the ma rket. A private business can, and will, change its prices in order to maintain an equilibrium of supply and demand. During a recession, this means lowering prices in order to combat the lowering demand for their products. Colleges and Universities on the other hand react differently to a recession. They raise their prices to combat budget cuts from the State and Federal levels. They still have their costs for teaching their students, and these costs do not normally change as quickly as the overall CPI. This would lead to the belief that college prices would fall again at the end of a recession, but colleges and universities are always hesitant to lower tuition. Coupled with the slower reaction time of colleges from market forces, the price stays at its elevated level far into the economic recovery. It would seem that the Economics 101 story around higher education for the past few decades would go something like this: for various reasons, government has decided to increase demand fo r higher education massively, via increased subsidies, and in particular student loans; meanwhile, supply has not kept up. This is because non-profit universities get paid in prestige and therefore have an objective

How Does Williams want us to feel about Blanche in the opening scene Free Essays

At the start of the scene, the Blanche is introduced dressed conspicuously in white, â€Å"as if she were arriving at a summer tea or cocktail party†. Williams is trying to portray a sense of youth, innocence and purity in her clothing, but she is obviously out of place; however she is also described as a â€Å"moth†-an unpleasant creature of the dark, so there is obviously more to her than meets the eye. She has an air of great self-importance and she is posh, and therefore slightly out of place. We will write a custom essay sample on How Does Williams want us to feel about Blanche in the opening scene? or any similar topic only for you Order Now She is used to grander settings than Elysian Fields: â€Å"Her expression is one of shocked disbelief†. She is also unimpressed at the state of her sister’s house. She is also very rude and dismissive towards people of lower status, like her overly-helpful neighbour Eunice. After at first failing to get rid of her with boring, one-word answers, she frankly tells her to go away: â€Å"What I meant was I’d like to be left alone†, offending Eunice. She feels superior to Eunice, and is not used to having to answer questions from people she deems to be below her. Once alone, Blanche begins to explore her sister’s house. Her eye is caught by a bottle of whiskey in a half-opened closet, and we find out that she is no novice when it comes to drinking. Whereas before she was sitting â€Å"in a chair very stiffly with her shoulders slightly hunched†, now she â€Å"springs up and crosses to it (the whiskey)†. She ‘tosses down’ half a tumbler, before hiding the evidence, thus revealing her secretive nature. This theme of her secret drinking habit continues throughout the first scene, as she lies about drinking and even has the temerity to claim that ‘one’s her limit’. She is also patronising and rude towards Stella. She joyously embraces her sister, talking far too much while trying to maintain her disguise: â€Å"turn that light off!†¦I won’t be looked at in this merciless glare!† She doesn’t want her sister to see that she is drunk or see through the facade of youthfulness. She then orders her about patronisingly while condemning her home: â€Å"What are you doing in a place like this?† After at first putting up with her sister’s degrading comments about her house, Stella describes her as â€Å"intense†, which describes her perfectly. Blanche is also very quick to accuse her sister, in a bid to deflect attention away from her own short-comings: â€Å"You thought I’d been fired?† She leaves a lot of things unsaid, such as her reason for leaving her job. She also feels the need for approval from her sister, especially appearance-wise. She orders Stella to â€Å"stand up†, before patronisingly referring to her as a â€Å"little partridge† and informing her that she’s â€Å"put on some weight†. Her sister puts up with it thought, obligingly telling her: â€Å"It’s just incredible, Blanche, how well you’re looking†. Blanch is very quick to judge, right from the very start; she is unimpressed by the local area, the neighbours, her sister’s home and even her husband’s nationality; she ignorantly refers to Polish people as â€Å"something like the Irish, aren’t they†¦only not so – highbrow?† She is keen to impose herself upon the local community, again showing her insatiable need to be liked by others. Eventually she moves on to why she came to be here, apart from â€Å"taking a leave of absence† from the school. She gives some lame excuses, like â€Å"I want to be near you† but betrays her cover with the stage direction â€Å"Her voice drops and her look is frightened†. However she is able to recover herself enough to launch into a hyperbolic defence of herself after losing the family home, even blaming Stella for leaving: â€Å"You’re a fine one to sit there accusing me of it!† She also exaggerates greatly, claiming â€Å"I fought for it, bled for it, almost died for it†. How to cite How Does Williams want us to feel about Blanche in the opening scene?, Papers